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KMID : 0363420060200010015
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Journal of Korean Oriental Pediatrics
2006 Volume.20 No. 1 p.15 ~ p.29
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Effects of NaesowhajungtangGamibang of Serum Cytokines of patients with Atopic Dermatitis
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Lee Jin-Yong
Kim Deog-Gon
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Abstract
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Objective: Based on the Th1/Th2 inbalance hypothesis, we aimed to evaluate the effects of NaesowhajungtongGamibang on serum $interferon{\gamma}$, interleukin-4, interleukin-5, of 19 patients with atopic dermatitis.
Materials and Methods: The subjects are consisted of 19 patients with atopic dermatitis, and had been treated with NaesowhajungtongGamibang decoction for 45 days. Serum $IFN-{\gamma}$, IL-4, IL-5 level were checked before and 45 days after treatments.
Results: The serum $IFN-{\gamma}$, IL-5, level in patients with atopic dermatitis were slightly decreased compared with normal control group, but had no statistical significance. The serum IL-4, level in patients with atopic dermatitis was slightly increased compared with normal control group, but had no statistical significance. After treatment with NaesowhajungtongGamibang for 45 days, serum $IFN-{\gamma}$, IL-5, level were increased, but had no statistical significance. After treatment with NaesowhajungtongGamibang for 45 days, serum IL-4 level were decreased, but had no statistical significance.
Conclusion: This study shows that NaesowhajungtongGamibang decoction had effects were not correspond with Th1/Th2 inbalance hypothesis. Therefore study for other mechanism of NaesowhajungtongGamibang on atopic dermatitis is required.
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KEYWORD
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NaesowhajungtongGamibang, Atopic Dermatitis, Th1/Th2 inbalance, $IFN-{\gamma}$, IL-4, IL-5
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